Treatment and Management of Primary Hyperoxaluria

November 3–8, 2025 is Hyperoxaluria Awareness Week.Primary hyperoxaluria (PH) is a rare genetic disease that has three types: PH1, PH2 and PH3. Less than 5,000 people in the U.S. have PH, many of whom are children.Your liver produces a waste product called oxalate — if you have PH, you overproduce oxalate and it builds up, causing kidney stones. Unfortunately, many people who have the disease don’t know it until their kidneys stop working. Eight out of 10 people with PH have PH1, which is the most serious type of primary hyperoxaluria, and it causes the most severe symptoms.​Treating and manag